Researchers at YALE School of Medicine have found that a compound (B-hydroxbutyrate, Ketone) produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease.
In their study, published in the Feb. 16 online issue of Nature Medicine, the researchers described how the compound β-hydroxybutyrate (BHB) directly inhibits NLRP3, which is part of a complex set of proteins called the inflammasome. The inflammasome drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer’s disease, atherosclerosis, and autoinflammatory disorders.
“These findings are important because endogenous metabolites like BHB that block the NLRP3 inflammasome could be relevant against many inflammatory diseases, including those where there are mutations in the NLRP3 genes,” said Vishwa Deep Dixit, professor in the Section of Comparative Medicine at Yale School of Medicine.
BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet.
Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation.
Working with mice and human immune cells, Dixit and colleagues focused on how macrophages — specialized immune cells that produce inflammation — respond when exposed to ketone bodies and whether that impacts the inflammasone complex.
The team introduced BHB to mouse models of inflammatory diseases caused by NLP3. They found that this reduced inflammation, and that inflammation was also reduced when the mice were given a ketogenic diet, which elevates the levels of BHB in the bloodstream.
“Our results suggest that the endogenous metabolites like BHB that are produced during low-carb dieting, fasting, or high-intensity exercise can lower the NLRP3 inflammasome,” said Dixit.
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My Take Away
I’ve been using a exogenous ketone product (β-hydroxybutyrate) for the last several weeks and the full use of the Isagenix 30-Day Cleansing and Fat Burning System. I’m insulin resistant and over the past 24 months have not been able to reduce the fat around my waist using methods that has previously worked for the past 11 years. During my use of the ketone product I’ve been able to release 12 pounds of fat primarily because I can induce ketosis and put my body into strict fat burning even though I have stores of glucose in my body.
In addition to the ketones I’ve also changed my food macros to approximately:
I acquire the extra fat from 3 additional sources; MCT Oil, Coconut oil and Red Palm Oil.
My exercise has been 100% in zone two (fat burning). I’ve not purposely counted calories. Following the instructions using the ketones I’ve eaten when I was hungry.
There are several ketone supplements on the market and you may purchase them either directly from their company or through Amazon.
I’m a leading distributor for Isagenix however have no financial interest in the ketone products.